Development of multifunctional polymer-mineral composite materials for bone tissue engineering

• Published in: Journal of biomedical materials research. Part A Vol. 75A; no. 2; pp. 333 - 341
• Main Authors: Vlakh, Evgenia G., Panarin, Evgeniy F., Tennikova, Tatiana B., Suck, Kirstin, Kasper, Cornelia
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.11.2005
• Subjects: Adsorption; biocompatible polymers; biomaterials; Bone and Bones - cytology; Bone and Bones - physiology; Bone Substitutes - chemistry; Bone Substitutes - metabolism; bone tissue engineering; Cell Line; Coated Materials, Biocompatible - chemistry; Coated Materials, Biocompatible - metabolism; composites; Humans; Lysine - chemistry; Minerals - chemistry; Molecular Structure; N-VP-DAAc; Polymers - chemistry; Pyrrolidinones - chemistry; Pyrrolidinones - metabolism; scaffold; Tissue Engineering - methods
• ISSN: 1549-3296; 1552-4965
• DOI: 10.1002/jbm.a.30428

The main goal of this article is the development of a novel approach to construct multifunctional composite scaffolds for bone tissue engineering. For this purpose, different kinds of mineral macroporous supports, water‐soluble aldehyde‐containing copolymers of N‐vinylpyrrolidone, as well as different nonspecific and biospecific ligands governing cell adhesion and growth have been used. The composite materials were tested initially for cytotoxicity in cell culture experiments using a model cell line. © 2005 Wiley Periodicals, Inc. J Biomed Mater Res, 2005