Treatment of Helicobacter pylori infection with a combination of itraconazole and omeprazole

• Published in: Alimentary pharmacology & therapeutics Vol. 9; no. 3; pp. 327 - 328
• Main Authors: KELLER, J. J., HULST, R. W. M., TYTGAT, G. N. J.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.06.1995; Blackwell
• Subjects: Adult; Aged; Biological and medical sciences; Digestive system; Drug Therapy, Combination; Female; Helicobacter Infections - drug therapy; Helicobacter pylori; Humans; Itraconazole - administration & dosage; Male; Medical sciences; Middle Aged; Omeprazole - administration & dosage; Pharmacology. Drug treatments; Pilot Projects; Human; Drug combination; Spirillales; Enzyme; Dyspepsia; Treatment efficiency; Spirillaceae; H; Enzyme inhibitor; K; Antifungal agent; Chemotherapy; Treatment; Helicobacter pylori; Triazole derivatives; Digestive diseases; Bacteria; Hydrolases; exchanging ATPase
• ISSN: 0269-2813; 1365-2036
• DOI: 10.1111/j.1365-2036.1995.tb00389.x

SUMMARY Aim : To determine the in vivo anti‐microbial activity of a high‐dose itraconazole and omeprazole regimen against Helicobacter pylori. Methods: In an open pilot study, 10 H. pylori positive dyspeptic patients were treated with itraconazole 200 mg b.d. and omeprazole 200 mg b.d. for 7 days. Follow‐up upper gastrointestinal endoscopy was performed 4–5 weeks after completion of therapy. Eradication of H. pylori infection was determined by histopathological examination and culture of biopsies from the antrum and corpus. Results: Eradication was not observed in any patient. Conclusion: This combination of itraconazole with omeprazole does not eradicate H. pylori infection.