A Cross-Metathesis Route to Functionalized α-Methyl α-Substituted Amino Acids

A chemoenzymatic approach to the synthesis of functionalized α‐methyl α‐substituted amino acids is detailed. This involves amidase‐mediated enzymatic resolution of α‐methyl α‐substituted side‐chain ω‐unsaturated amino acids followed by functionalization via cross‐metathesis.

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Bibliographic Details
Published inAdvanced synthesis & catalysis Vol. 349; no. 1-2; pp. 161 - 164
Main Authors Storcken, Roy P. M., Panella, Lavinia, van Delft, Floris L., Kaptein, Bernard, Broxterman, Quirinus B., Schoemaker, Hans E., Rutjes, Floris P. J. T.
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 08.01.2007
WILEY‐VCH Verlag
Wiley
Subjects
amino amidase
Chemistry
Chemistry, Applied
Chemistry, Organic
cross-metathesis
enzyme catalysis
Physical Sciences
Science & Technology
side-chain ω-unsaturated α-amino acids
α-methyl α-substituted amino acids
amino amidase
cross-metathesis
RING-CLOSING METATHESIS
alpha-methyl alpha-substituted amino acids
side-chain omega-unsaturated alpha-amino acids
enzyme catalysis
STEREOSELECTIVE-SYNTHESIS
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Summary:A chemoenzymatic approach to the synthesis of functionalized α‐methyl α‐substituted amino acids is detailed. This involves amidase‐mediated enzymatic resolution of α‐methyl α‐substituted side‐chain ω‐unsaturated amino acids followed by functionalization via cross‐metathesis.
Bibliography:ark:/67375/WNG-C3KN10L4-M
ArticleID:ADSC200600446
istex:4B3424E8A4634FF5D464D01D9864F0018724A08A
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.200600446