Dermabrasion for Acne Scars During Treatment with Oral Isotretinoin

• Published in: Dermatologic surgery Vol. 36; no. 4; pp. 483 - 489
• Main Authors: BAGATIN, EDILÉIA, DOS SANTOS GUADANHIM, LILIA RAMOS, YARAK, SAMIRA, KAMAMOTO, CRISTHINE SOUZA LEÃO, DE ALMEIDA, FERNANDO AUGUSTO
• Format: Journal Article
• Language: English
• Published: Malden, USA Blackwell Publishing Inc 01.04.2010; Wiley
• Subjects: Acne Keloid - etiology; Acne Keloid - surgery; Acne Vulgaris - complications; Acne Vulgaris - drug therapy; Administration, Oral; Adolescent; Adult; Biological and medical sciences; Cicatrix, Hypertrophic - etiology; Cicatrix, Hypertrophic - surgery; Combined Modality Therapy; Dermabrasion - methods; Dermatologic Agents - administration & dosage; Dermatology; Face; Female; Humans; Isotretinoin - administration & dosage; Isotretinoin - adverse effects; Male; Medical sciences; Patient Satisfaction; Prospective Studies; Skin involvement in other diseases. Miscellaneous. General aspects; Skin plastic surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Treatment Outcome; Wound Healing; Young Adult; Skin disease; Treatment; Dermatology; Acne; Surgery; Scar; Oral administration; Isotretinoin; Dermabrasion
• ISSN: 1076-0512; 1524-4725
• DOI: 10.1111/j.1524-4725.2010.01474.x

BACKGROUND Oral isotretinoin is the criterion standard treatment for severe inflammatory acne associated with scar development. Atypical or exaggerated cicatrization related to oral isotretinoin was reported throughout the 1980s and 1990s. Dermabrasion for atrophic acne scar revision is not recommended 6 to 12 months from the end of oral isotretinoin treatment. OBJECTIVE To evaluate wound healing after localized dermabrasion in patients receiving oral isotretinoin. MATERIALS & METHODS Interventional, prospective study involving seven patients taking oral isotretinoin to treat acne and with atrophic acne scars on the face. Manual dermabrasion was performed on all patients in an area of approximately 1 cm2, and a 6‐month reepithelization follow‐up by clinical evaluation was conducted. RESULTS All patients presented normal cicatrization evolution; hypertrophic scarring or keloid as a result of localized abrasion was not observed, and atrophic acne scar revision result was excellent. CONCLUSION The current recommendation to wait 6 to 12 months after treatment with oral isotretinoin for acne scar revision using dermabrasion should be re‐evaluated. Abrasion of a small test area may be a useful predictor of wound healing, enabling earlier acne scar treatment using this procedure. The authors have indicated no significant interest with commercial supporters.