Relationship between dose and serum concentrations of carbamazepine, phenytoin, phenobarbital, and primidone in a Sri Lankan population compared with a European population

Concentrations of carbamazepine, phenytoin, phenobarbital, and primidone have been measured by high pressure liquid chromatography (HPLC) in serums of 177 Sri Lankan epileptic patients. Relationships between concentrations and dose per kg body weight of these drugs have been compared with those of p...

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Published inEpilepsia (Copenhagen) Vol. 29; no. 5; p. 564
Main Authors Peiris, J B, Karunanayake, E H, Joice, P D, Goedhart, D M, Meijer, J W, Meinardi, H
Format Journal Article
LanguageEnglish
Published United States 01.09.1988
Subjects
Adolescent
Adult
Anticonvulsants - blood
Anticonvulsants - therapeutic use
Carbamazepine - blood
Carbamazepine - therapeutic use
Child
Epilepsy - blood
Epilepsy - drug therapy
Europe
Female
Humans
Male
Middle Aged
Phenobarbital - blood
Phenobarbital - therapeutic use
Phenytoin - blood
Phenytoin - therapeutic use
Primidone - blood
Primidone - therapeutic use
Sri Lanka
Sri Lanka
Europe
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Summary:Concentrations of carbamazepine, phenytoin, phenobarbital, and primidone have been measured by high pressure liquid chromatography (HPLC) in serums of 177 Sri Lankan epileptic patients. Relationships between concentrations and dose per kg body weight of these drugs have been compared with those of patients in the Netherlands, using a matching procedure. Although variabilities in dose-concentration ratios were somewhat larger in Sri Lanka than in the Netherlands, no evidence was found of a systematic difference in pharmacokinetics between both populations.
ISSN:0013-9580
DOI:10.1111/j.1528-1157.1988.tb03762.x