The assessment of gastric acidity and antacid effect in pregnant women by a non-invasive radiotelemetry technique
Non-invasive radiotelemetry techniques were used for the in-vivo assessment of gastric acidity and the effect of antacids in non-pregnant women and women in the third trimester of pregnancy. A particulate (magnesium trisilicate mixture) and a non-particulate (sodium citrate) antacid were studied. Th...
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Published in | British journal of obstetrics and gynaecology Vol. 91; no. 10; p. 973 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
England
01.10.1984
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Subjects | |
Online Access | Get more information |
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Summary: | Non-invasive radiotelemetry techniques were used for the in-vivo assessment of gastric acidity and the effect of antacids in non-pregnant women and women in the third trimester of pregnancy. A particulate (magnesium trisilicate mixture) and a non-particulate (sodium citrate) antacid were studied. There was no significant difference in basal gastric acidity and gut transit time between the pregnant and non-pregnant subjects. The median and range of values for the efficacy (defined as the integrated area under the pH/time curves) of sodium citrate was 138.3 pH.min (29.8-520.7) in the non-pregnant and 103.0 pH.min (54.3-375.6) in the pregnant subjects. The median and range of values for the duration of action of sodium citrate were 38.6 (18.1-147.4) min in the non-pregnant and 30.5 (20.0-119.1) min in the pregnant women. Magnesium trisilicate mixture resulted in a greater intragastric pH change and had a greater efficacy than sodium citrate, but the duration of action of the two antacids was similar. |
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ISSN: | 0306-5456 |
DOI: | 10.1111/j.1471-0528.1984.tb03673.x |