Forearm vascular responses to serotonin are not mediated by products of cyclooxygenase

The involvement of cyclooxygenase‐derived substances in the forearm arteriolar responses to serotonin was determined in 10 healthy male volunteers. Serotonin was infused in five incremental doses (0.003–30 μg min‐1) for 2 min each into the brachial artery of the non‐dominant forearm. Forearm blood f...

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Published inBritish journal of clinical pharmacology Vol. 41; no. 3; pp. 241 - 243
Main Authors NUGENT, A. G., McGURK, C., JOHNSTON, G. D.
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.03.1996
Blackwell Science
Subjects
Adult
Arm - blood supply
Biological and medical sciences
Blood Flow Velocity - drug effects
cyclooxygenase
Dose-Response Relationship, Drug
forearm blood flow
Fundamental and applied biological sciences. Psychology
Hemodynamics. Rheology
Humans
indomethacin
inhibition
Male
Prostaglandin-Endoperoxide Synthases - pharmacology
serotonin
Serotonin - pharmacology
Vertebrates: cardiovascular system
Human
Prostaglandin-endoperoxide synthase
Serotonin
Enzyme
Arteriole
Enzyme inhibitor
Normal
Artery
Blood flow
Blood vessel
Oxidoreductases
Circulatory system
Hemodynamics
Mechanism of action
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Summary:The involvement of cyclooxygenase‐derived substances in the forearm arteriolar responses to serotonin was determined in 10 healthy male volunteers. Serotonin was infused in five incremental doses (0.003–30 μg min‐1) for 2 min each into the brachial artery of the non‐dominant forearm. Forearm blood flow (FBF) responses to each dose were measured by strain‐gauge venous occlusion plethysmography. The cyclooxygenase inhibitor indomethacin (100mg) was administered orally following the serotonin infusions. After 90 min the serotonin infusions were repeated and FBF responses measured. Serotonin caused a biphasic response with vasodilatation occurring at low doses (0.003‐3 μg min‐1, P < 0.01) and vasoconstriction occurring at the highest dose (P < 0.01). There was no significant difference in vascular response to serotonin following cyclooxygenase inhibition. In conclusion, cyclooxygenase products are not involved in the forearm vascular responses to serotonin in healthy human subjects.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0306-5251
1365-2125
DOI:10.1111/j.1365-2125.1996.tb00189.x