Use of the discriminant index in dynamic treatment to reduce recurrence of calcium oxalate kidney stones

Treatment with phosphates, thiazides and allopurinol was undertaken in 54 idiopathic calcium oxalate stone formers, 38 of whom were recurrent stone formers. The patients were followed up for 1 1/2 to 4 years (mean 2.6). During the same period at the pre-treatment stage the patients formed 80 stones,...

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Bibliographic Details
Published inBritish journal of urology Vol. 57; no. 5; p. 500
Main Authors Perlberg, S, Azoury, R, Garti, N, Sarig, S
Format Journal Article
LanguageEnglish
Published England 01.10.1985
Subjects
Adult
Aged
Allopurinol - therapeutic use
Calcium - urine
Calcium Oxalate
Chlorothiazide - therapeutic use
Diphosphates - therapeutic use
Female
Follow-Up Studies
Humans
Kidney Calculi - prevention & control
Kidney Calculi - urine
Male
Middle Aged
Recurrence
Uric Acid - urine
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Summary:Treatment with phosphates, thiazides and allopurinol was undertaken in 54 idiopathic calcium oxalate stone formers, 38 of whom were recurrent stone formers. The patients were followed up for 1 1/2 to 4 years (mean 2.6). During the same period at the pre-treatment stage the patients formed 80 stones, but during therapy only one stone was formed. A dynamic scheme of therapy was used. Each patient was tested before the start of drug treatment by the discriminant index (DI) method, which measures the overall inhibitory potential to calcium oxalate crystallisation. About 10 days after the start of treatment the DI was tested again. If the response was positive, therapy was continued; if not, the patient was given another drug. Adjustments were made as required. The stopping of stone formation correlated well with the DI prediction but less well with the hypocalciuric effect of the drugs.
ISSN:0007-1331
DOI:10.1111/j.1464-410X.1985.tb05855.x