An efficient one-pot synthesis of 2,3-epoxyl-1,3-diaryl-1-propanone directly from acetophenones and aromatic aldehydes under ultrasound irradiation

• Published in: Ultrasonics sonochemistry Vol. 17; no. 2; pp. 363 - 366
• Main Authors: Li, Ji-Tai, Yin, Ying, Sun, Ming-Xuan
• Format: Journal Article
• Language: English
• Published: AMSTERDAM Elsevier B.V 01.02.2010; Elsevier
• Subjects: 2,3-Epoxyl-1,3-diaryl-1-propanone; Acetophenones - chemistry; Acoustics; Aldehydes - chemistry; Aromatic aldehyde; Benzaldehydes - chemistry; Chemistry; Chemistry, Multidisciplinary; Chemistry, Organic - methods; Epoxidation; Epoxy Compounds - chemical synthesis; Exact sciences and technology; General and physical chemistry; Hydroxides - chemistry; Magnetic Resonance Spectroscopy; Models, Chemical; Physical chemistry of induced reactions (with radiations, particles and ultrasonics); Physical Sciences; Potassium Compounds - chemistry; Propane - chemical synthesis; Science & Technology; Solvents - chemistry; Synthesis; Technology; Temperature; Time Factors; Ultrasonic chemistry; Ultrasonics; Ultrasound irradiation; Epoxidation; Synthesis; Aromatic aldehyde; 2,3-Epoxyl-1,3-diaryl-1-propanone; Ultrasound irradiation; ALPHA,BETA-UNSATURATED KETONES; ASYMMETRIC EPOXIDATION; CATALYST; Sonochemistry; Aldehyde; Ketone; Energy; Acetophenone; Reaction time; Benzenic compound; Ultrasound; Room temperature
• ISSN: 1350-4177; 1873-2828
• DOI: 10.1016/j.ultsonch.2009.09.007

A convenient and efficient one-pot synthesis of 2,3-epoxyl-1,3-diaryl-1-propanone directly from acetophenones and aromatic aldehydes under ultrasound irradiation at room temperature has been described. In comparison to two-step methods, the present procedure has the advantages of mild conditions, shorter reaction time, without isolation of any intermediate, saves energy and no requirement of toxic solvent.