Stimulation of interleukin 2 and interferon gamma production by leukotriene B4 in human lymphocyte cultures

• Published in: Prostaglandins leukotrienes and medicine Vol. 23; no. 2-3; pp. 207 - 210
• Main Authors: ROLA-PLESZCZYNSKI, M, CHAVAILLAZ, P.-A, LEMAIRE, I
• Format: Journal Article
• Language: English
• Published: Edinburgh Churchill Livingstone 01.08.1986; New York, NY
• Subjects: Analysis of the immune response. Humoral and cellular immunity; Antibodies, Monoclonal; Biological and medical sciences; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Humans; Immunobiology; Indomethacin - pharmacology; Interferon-gamma - biosynthesis; Interleukin-2 - biosynthesis; Leukotriene B4 - immunology; Leukotriene B4 - pharmacology; Lymphocyte Activation - drug effects; Lymphocyte Depletion; Lymphocytes - drug effects; Lymphocytes - metabolism; Miscellaneous; Phytohemagglutinins - pharmacology; Regulatory factors and their cellular receptors; T-Lymphocytes, Helper-Inducer - metabolism; T-Lymphocytes, Regulatory - classification; T-Lymphocytes, Regulatory - immunology; Human; Cell culture; Interleukin 2; Arachidonic acid derivatives; Leucotriene B4; Production; Biosynthesis; Immune regulation; Lymphokine; Mechanism of action; Lymphocyte; Gamma interferon
• ISSN: 0262-1746
• DOI: 10.1016/0262-1746(86)90187-3

Interleukin 2 (IL-2) and interferon-gamma (IFN) production by human lymphocytes was significantly enhanced in the presence of leukotriene B4 (LTB4) and indomethacin. Depletion of the T8+ suppressor cell subset of human T cells resulted in enhanced lymphokine production and further augmentation by LTB4. These findings suggest that LTB4 can regulate immune responses through its modulation of lymphokine production.