Assessment Of Renal Function Using Canine Cystatin-C Levels In Canine Babesiosis And Ehrlichiosis

• Published in: Acta veterinaria (Beograd) Vol. 65; no. 1; pp. 56 - 65
• Main Authors: Didem, PEKMEZCI, Kerem, URAL, Nuran, AYSUL, Murat, GUZEL, Gulay, CIFTCI
• Format: Journal Article
• Language: English
• Published: De Gruyter Open 01.03.2015; Sciendo
• Subjects: babesia canis vogeli; Canine; Cystatin-C; ehrlichia canis; Renal function
• ISSN: 1820-7448; 1820-7448
• DOI: 10.1515/acve-2015-0004

The purpose of the present study was to evaluate serum canine Cystatin-C (Cys-C) concentration for the prediction of renal function (RF) in dogs naturally infected with and A total of 46 dogs were enrolled into three groups. Group B included 16 dogs naturally infected with , group E 10 dogs naturally infected with [dogs diagnosed as canine monocytic ehrlichiosis (CME)], and group H involved 20 healthy controls (negative for and ). Solely dogs presenting uncomplicated babesiosis caused by were enrolled. Serum urea and serum creatinine (Cre) levels with serum Urea:Cre ratios were analyzed. Canine serum Cys-C was determined with a species-specific commercially available and validated ELISA assay as a reference. Mean serum Cys-C levels were 5.28 mg/L, 3.02 mg/L, and 2.30 mg/L for groups B, E and H, respectively. RF in uncomplicated CB caused by seems to be affected based on serum Cys-C concentrations. To the author's knowledge, this is the first study reporting that mean serum canine Cys-C levels in dogs with CME demonstrated no elevation. Serum canine Cys-C as a novel RF marker could be used for early detection of renal injury in both babesiosis and CME.