Camouflaged angiogenic BMP-2 functions exposed by pico-paracrine biohybrids

The constant release of human bone morphogenetic protein 2 (rhBMP-2) in the picomolar range (Pico-Stat) from PDLLA-biohybrids led to the detection of intrinsic novel pro- and anti-angiogenic functions of this cytokine. As integrant part in this perspective of previous work, first evidence for the bi...

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Bibliographic Details
Published inFrontiers in bioengineering and biotechnology Vol. 11; p. 1226649
Main Author Jennissen, Herbert P.
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 07.09.2023
Subjects
allosteric inverse agonist
angioinduction
Bioengineering and Biotechnology
constitutive receptor activity
orthosteric agonist
osteoinduction
pico-technology
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Summary:The constant release of human bone morphogenetic protein 2 (rhBMP-2) in the picomolar range (Pico-Stat) from PDLLA-biohybrids led to the detection of intrinsic novel pro- and anti-angiogenic functions of this cytokine. As integrant part in this perspective of previous work, first evidence for the binding of rhBMP-2, as an inverse agonist , to allosteric angiogenic receptors in cocultures of human endothelial cells is reported.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Edited by: Babatunde Okesola, University of Nottingham, United Kingdom
Reviewed by: Cosimo Ligorio, University of Nottingham, United Kingdom
ISSN:2296-4185
2296-4185
DOI:10.3389/fbioe.2023.1226649