MutHTP: mutations in human transmembrane proteins

• Published in: Bioinformatics Vol. 34; no. 13; pp. 2325 - 2326
• Main Authors: Kulandaisamy, A, Binny Priya, S, Sakthivel, R, Tarnovskaya, Svetlana, Bizin, Ilya, Hönigschmid, Peter, Frishman, Dmitrij, Gromiha, M Michael
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.07.2018
• ISSN: 1367-4803; 1460-2059; 1367-4811
• DOI: 10.1093/bioinformatics/bty054

Abstract Motivation Existing sources of experimental mutation data do not consider the structural environment of amino acid substitutions and distinguish between soluble and membrane proteins. They also suffer from a number of further limitations, including data redundancy, lack of disease classification, incompatible information content, and ambiguous annotations (e.g. the same mutation being annotated as disease and benign). Results We have developed a novel database, MutHTP, which contains information on 183 395 disease-associated and 17 827 neutral mutations in human transmembrane proteins. For each mutation site MutHTP provides a description of its location with respect to the membrane protein topology, structural environment (if available) and functional features. Comprehensive visualization, search, display and download options are available. Availability and implementation The database is publicly available at http://www.iitm.ac.in/bioinfo/MutHTP/. The website is implemented using HTML, PHP and javascript and supports recent versions of all major browsers, such as Firefox, Chrome and Opera. Supplementary information Supplementary data are available at Bioinformatics online.