Voluntary intake of calcium and other minerals by rats

The voluntary intake by male Sprague-Dawley rats of five calcium salts and eight mineral chlorides was assessed. Groups of 12-25 rats received a series of 48-h two-bottle tests with a choice between water and ascending concentrations of a mineral solution. Similar inverted U-shaped concentration-int...

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Bibliographic Details
Published inThe American journal of physiology Vol. 267; no. 2; p. R470
Main Author Tordoff, M.G
Format Journal Article
LanguageEnglish
Published United States 01.08.1994
Subjects
Animals
APETITO
APPETIT
CALCIO
CALCIUM
Calcium Chloride - administration & dosage
Calcium, Dietary - administration & dosage
Chlorides - administration & dosage
CHLORURE
CLORUROS
DIETA
Drinking
Food Preferences
Male
MINERALES
Minerals - administration & dosage
MINERAUX
Osmolar Concentration
PREFERENCE ALIMENTAIRE
PREFERENCIAS ALIMENTARIAS
RAT
RATA
Rats
Rats, Sprague-Dawley
REGIME ALIMENTAIRE
SALES
SEL
Solutions
Volition
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Summary:The voluntary intake by male Sprague-Dawley rats of five calcium salts and eight mineral chlorides was assessed. Groups of 12-25 rats received a series of 48-h two-bottle tests with a choice between water and ascending concentrations of a mineral solution. Similar inverted U-shaped concentration-intake functions were obtained with each of the five calcium salts tested (hydroxide, gluconate, phosphate, lactate, and chloride): rats drank more calcium solution than water at concentrations between approximately 0.2 and 5 mM, showed indifference between 5 and 12 mM, and avoided higher concentrations. Inverted U-shaped concentration-intake functions were also obtained for ammonium chloride (peak at 100 mM), magnesium chloride (peak at 10 micromolar), potassium chloride (peak at 10 mM), ferrous chloride (peak at 4.64 micromolar), and rubidium chloride (peak at 2.15 micromolar). Rats drank slightly and nonsignificantly more 2.15 micromolar aluminum chloride than water and never drank more zinc chloride than water (range tested, 1 micromolar to 464 mM). These results illustrate that, as is the case for sodium, rats spontaneously ingest low concentrations of calcium and several other mineral solutions in preference to water. In general, the lower the cation's ionic charge, the greater the intake and higher the most accepted concentration
Bibliography:S01
9516813
ISSN:0002-9513
2163-5773
DOI:10.1152/ajpregu.1994.267.2.r470