Changes in coagulation and fibrinolysis of post-SARS osteonecrosis in a Chinese population

• Published in: International orthopaedics Vol. 30; no. 3; pp. 143 - 146
• Main Authors: Sun, Wei, Li, Zi-rong, Shi, Zhen-cai, Zhang, Nian-fei, Zhang, Yuan-chun
• Format: Journal Article
• Language: English
• Published: Germany Springer-Verlag 01.06.2006
• Subjects: Adult; Blood Coagulation; Blood Coagulation Tests; China; Fibrinolysis; Humans; Middle Aged; Original Paper; Osteonecrosis - blood; Osteonecrosis - etiology; Osteonecrosis - virology; Partial Thromboplastin Time; Plasminogen Inactivators - pharmacology; Severe Acute Respiratory Syndrome - blood; Tissue Plasminogen Activator - metabolism; China
• ISSN: 0341-2695; 1432-5195
• DOI: 10.1007/s00264-005-0067-6

The purpose of this study was to detect changes in coagulation and fibrinolysis of post-severe acute respiratory syndrome (SARS) Chinese patients with osteonecrosis, investigate the aetiology of post-SARS osteonecrosis (ON), and select the sensitive molecular markers for identifying the susceptible population. For this study, blood samples were collected from 88 patients with post-SARS ON and 52 healthy people. Activated partial thromboplastin time (APTT), protein C (PC), antithrombin III (AT-III), plasminogen activator inhibitor (PAI), activated protein C resistance (APC-R), plasminogen (PLG), von Willebrand's factor(vWF), D-dimer (D-D), fibrinogen (Fib), and homocysteine (HCY) were examined by enzyme-linked immunosorbent assay (ELISA). We noted that blood agents of patients with ON changed obviously. APTT, PC, AT-III, PAI, APC-R, and PLG were significantly different between the two groups. Hypercoagulation and hypofibrinolysis were found in patients with post-SARS ON. Therefore, these examinations can be used to screen a population susceptible to ON. Measurements of APTT, PC, AT-III, PAI, APC-R, and PLG are sensitive blood tests for screening purposes.