CSF-chemokines in HTLV-I-associated myelopathy: CXCL10 up-regulation and therapeutic effect of interferon-α

• Published in: Journal of neuroimmunology Vol. 159; no. 1; pp. 177 - 182
• Main Authors: Narikawa, Koichi, Fujihara, Kazuo, Misu, Tatsuro, Feng, Juan, Fujimori, Juichi, Nakashima, Ichiro, Miyazawa, Isabelle, Saito, Hiroshi, Sato, Shigeru, Itoyama, Yasuto
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.2005
• Subjects: Adult; Aged; Chemokine; Chemokine CCL11; Chemokine CCL17; Chemokine CCL2 - biosynthesis; Chemokine CCL2 - blood; Chemokine CCL2 - cerebrospinal fluid; Chemokine CXCL10; Chemokines, CC - blood; Chemokines, CC - cerebrospinal fluid; Chemokines, CXC - biosynthesis; Chemokines, CXC - blood; Chemokines, CXC - cerebrospinal fluid; Enzyme-Linked Immunosorbent Assay; Female; Human T-lymphotropic virus; Human T-lymphotropic virus 1; Human T-lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis; Humans; Interferon-alpha - therapeutic use; Male; Middle Aged; Multiple sclerosis; Multiple Sclerosis - cerebrospinal fluid; Multiple Sclerosis - immunology; Multiple Sclerosis - therapy; Paraparesis, Tropical Spastic - cerebrospinal fluid; Paraparesis, Tropical Spastic - immunology; Paraparesis, Tropical Spastic - therapy; Reagent Kits, Diagnostic; Th1; Th2; Up-Regulation - immunology; Chemokine; Multiple sclerosis; Human T-lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis; Th1; Th2
• ISSN: 0165-5728; 1872-8421
• DOI: 10.1016/j.jneuroim.2004.10.011

We measured four chemokines in the cerebrospinal fluid (CSF) in human T-lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) with ELISA. CXCL10/IP-10, a T cell type 1 (Th1)-associated chemokine, was significantly elevated in HAM/TSP compared with controls, and the values were even significantly higher in HAM/TSP than in multiple sclerosis (MS) in which CXCL10/IP-10 up-regulation was previously reported. Among Th2-associated chemokines, CCL17/TARC and CCL11/Eotaxin in HAM/TSP were not different from those in controls. As shown in MS, CCL2/MCP-1 was significantly lower in HAM/TSP than in control. Following interferon (IFN)-α therapy in HAM/TSP, CCL2/MCP-1 became significantly higher than that before therapy, which may reflect a Th2 induction, while CXCL10/IP-10 remained elevated.