Ondansetron in the treatment of intractable nausea associated with theophylline toxicity

To report the efficacy of ondansetron in the treatment of a patient poisoned with theophylline. A 36-year-old man who ingested 6 g of sustained-release theophylline. Ondansetron 8 mg intravenously after clinical failure of other antiemetics. Subjective relief of nausea within minutes, enabling the p...

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Bibliographic Details
Published inThe Annals of pharmacotherapy Vol. 27; no. 5; p. 584
Main Authors Sage, T A, Jones, W N, Clark, R F
Format Journal Article
LanguageEnglish
Published United States 01.05.1993
Subjects
Adult
Delayed-Action Preparations
Humans
Male
Nausea - drug therapy
Nausea - etiology
Ondansetron - therapeutic use
Poisoning - therapy
Theophylline - administration & dosage
Theophylline - poisoning
Vomiting - drug therapy
Vomiting - etiology
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Summary:To report the efficacy of ondansetron in the treatment of a patient poisoned with theophylline. A 36-year-old man who ingested 6 g of sustained-release theophylline. Ondansetron 8 mg intravenously after clinical failure of other antiemetics. Subjective relief of nausea within minutes, enabling the patient to tolerate multiple doses of activated charcoal and whole bowel irrigation. Ondansetron may offer an alternative to present antiemetic therapy in the poisoned patient.
ISSN:1060-0280
DOI:10.1177/106002809302700511