A continuous-flow resonator-type microwave reactor for high-efficiency organic synthesis and Claisen rearrangement as a model reaction

We have developed a single-mode microwave reactor for continuous-flow synthesis with various methods of operation. This device measures the resonant frequency and modulates the oscillation frequency accordingly to maintain the maximum electric field intensity in the cavity. It can be operated either...

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Bibliographic Details
Published inJournal of flow chemistry Vol. 8; no. 3-4; pp. 147 - 156
Main Authors Koyama, Emiko, Ito, Noriko, Sugiyama, Jun-ichi, Barham, Joshua P., Norikane, Yasuo, Azumi, Reiko, Ohneda, Noriyuki, Ohno, Yoshinobu, Yoshimura, Takeo, Odajima, Hiromichi, Okamoto, Tadashi
Format Journal Article
LanguageEnglish
Published Cham Springer International Publishing 01.12.2018
Subjects
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Green Chemistry
Industrial Chemistry/Chemical Engineering
Inorganic Chemistry
Nanochemistry
Organic Chemistry
Microwave
Claisen rearrangement
Single-mode microwave reactor
Flow synthesis
Continuous flow
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Summary:We have developed a single-mode microwave reactor for continuous-flow synthesis with various methods of operation. This device measures the resonant frequency and modulates the oscillation frequency accordingly to maintain the maximum electric field intensity in the cavity. It can be operated either using constant applied irradiation power or using new programs which change the electric power (E-GRA) and change the flow rate (Fl-GRA), in order to rapidly screen various reaction conditions. As a model reaction, the Claisen rearrangement reaction of allyl 1-naphthyl ether 1 was rapidly optimized in this device, affording the desired product 2-allylnapthalen-1-ol 2 in high (91%) yield and up to 20 g/h productivity.
ISSN:2062-249X
2063-0212
DOI:10.1007/s41981-018-0021-6