Carbapenem-Resistant Enterobacterales Infection After Massive Blast Injury: Use of Cefiderocol Based Combination Therapy

ABSTRACT A military soldier sustained a blast injury in Afghanistan, resulting in amputations and hemipelvectomy. He developed New Delhi metallo-beta-lactamase-producing E. coli bacteremia, soft-tissue infection, and sacral osteomyelitis. These organisms are being increasingly discovered in differen...

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Published inMilitary medicine Vol. 186; no. 11-12; pp. 1241 - 1245
Main Authors Carney, B.W, Rizzo, J A, Alderete, J F, Cindass, R, Markelz, A E, Cancio, L C
Format Journal Article
LanguageEnglish
Published US Oxford University Press 02.11.2021
Subjects
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Antibiotics
Bacterial infections
Blast Injuries - drug therapy
Carbapenems - pharmacology
Carbapenems - therapeutic use
Casualties
Cefiderocol
Cephalosporins
Combination therapy
Drug resistance
E coli
Escherichia coli
Humans
Male
Microbial Sensitivity Tests
Military medicine
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Summary:ABSTRACT A military soldier sustained a blast injury in Afghanistan, resulting in amputations and hemipelvectomy. He developed New Delhi metallo-beta-lactamase-producing E. coli bacteremia, soft-tissue infection, and sacral osteomyelitis. These organisms are being increasingly discovered in different communities around the world. He was successfully treated with tigecycline and cefiderocol. Cefiderocol is a novel siderophore-based cephalosporine developed to treat serious infections, including those caused by carbapenem-resistant Enterobacterales.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0026-4075
1930-613X
DOI:10.1093/milmed/usab350