A self-reporting AIE probe with a built-in singlet oxygen sensor for targeted photodynamic ablation of cancer cells

The real-time monitoring of reactive oxygen species (ROS, particularly singlet oxygen) generation during photodynamic therapy is a great challenge due to the extremely short half-life and small radius of action. To tackle this issue, we herein report a bioprobe composed of a red emissive photosensit...

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Published inChemical science (Cambridge) Vol. 7; no. 3; pp. 1862 - 1866
Main Authors Yuan, Youyong, Zhang, Chong-Jing, Xu, Shidang, Liu, Bin
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 01.03.2016
Subjects
Ablation
Cancer
Chemistry
Chemistry, Multidisciplinary
Emissivity
Fluorescence
Monitoring
Physical Sciences
Real time
Science & Technology
Singlet oxygen
Strategy
NANOPARTICLES
REACTIVE OXYGEN
FAR-RED
THERAPY
PRODRUG
VIVO
PHOTOSENSITIZERS
MAGNETIC-RESONANCE
DRUG-RELEASE
AGGREGATION-INDUCED-EMISSION
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Summary:The real-time monitoring of reactive oxygen species (ROS, particularly singlet oxygen) generation during photodynamic therapy is a great challenge due to the extremely short half-life and small radius of action. To tackle this issue, we herein report a bioprobe composed of a red emissive photosensitizer (PS) with aggregation-induced emission (AIE) characteristics and a fluorogenic green emissive rhodol dye conjugated via a singlet oxygen cleavable aminoacrylate (AA) linker. The probe emits red fluorescence in water, and the red emissive PS can be used for probe self-tracking. Upon image-guided light irradiation, the generated singlet oxygen cleaves the AA linker to yield green fluorescence turn-on of rhodol, which offers real-time and in situ monitoring of singlet oxygen generation during photodynamic ablation of cancer cells, providing a strategy for the early evaluation of the therapeutic effect.
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ISSN:2041-6520
2041-6539
DOI:10.1039/c5sc03583j