Proton pump inhibitors and risk of gastric cancer in a case–control study

In order to reduce the latency bias, subjects whose first-time prescriptions for proton pump inhibitors were noted ≤12 months before the index date were excluded from the study. [...]only those subjects whose first-time prescriptions for proton pump inhibitors were noted >12 months before the ind...

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Bibliographic Details
Published inGut Vol. 68; no. 4; pp. 765 - 767
Main Authors Lai, Shih-Wei, Lai, Hsueh-Chou, Lin, Cheng-Li, Liao, Kuan-Fu
Format Journal Article
LanguageEnglish
Published England BMJ Publishing Group LTD 01.04.2019
Subjects
Anti-Ulcer Agents
Bias
Case-Control Studies
Gastric cancer
Gastroesophageal reflux
Health risk assessment
Helicobacter pylori
Humans
Latency
Proton Pump Inhibitors
Protons
Stomach Neoplasms
United Kingdom > UK
Kuwait
China
Taiwan
case-control
gastric cancer
proton pump inhibitors
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Summary:In order to reduce the latency bias, subjects whose first-time prescriptions for proton pump inhibitors were noted ≤12 months before the index date were excluded from the study. [...]only those subjects whose first-time prescriptions for proton pump inhibitors were noted >12 months before the index date could be included. The latency bias could be reduced. [...]subjects included were those who needed proton pump inhibitors to treat their acid-related GI diseases rather than gastric cancer-related symptoms. Because stringent inclusion and exclusion criteria were applied, the eligible subject number was small.
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ISSN:0017-5749
1468-3288
1468-3288
DOI:10.1136/gutjnl-2018-316371