Causal associations between inflammatory bowel disease and anxiety: A bidirectional Mendelian randomization study
Anxiety is common in patients with inflammatory bowel disease (IBD), including those with ulcerative colitis (UC) and Crohn's disease (CD); however, the causal relationship between IBD and anxiety remains unknown. To investigate the causal relationship between IBD and anxiety by using bidirecti...
Saved in:
Published in | World journal of gastroenterology : WJG Vol. 29; no. 44; pp. 5872 - 5881 |
---|---|
Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
United States
Baishideng Publishing Group Inc
28.11.2023
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Anxiety is common in patients with inflammatory bowel disease (IBD), including those with ulcerative colitis (UC) and Crohn's disease (CD); however, the causal relationship between IBD and anxiety remains unknown.
To investigate the causal relationship between IBD and anxiety by using bidirectional Mendelian randomization analysis.
Single nucleotide polymorphisms retrieved from genome-wide association studies (GWAS) of the European population were identified as genetic instrument variants. GWAS statistics for individuals with UC (6968 patients and 20464 controls; adults) and CD (5956 patients and 14927 controls; adults) were obtained from the International IBD Genetics Consortium. GWAS statistics for individuals with anxiety were obtained from the Psychiatric Genomics Consortium (2565 patients and 14745 controls; adults) and FinnGen project (20992 patients and 197800 controls; adults), respectively. Inverse-variance weighted was applied to assess the causal relationship, and the results were strengthened by heterogeneity, pleiotropy and leave-one-out analyses.
Genetic susceptibility to UC was associated with an increased risk of anxiety [odds ratio: 1.071 (95% confidence interval: 1.009-1.135),
= 0.023], while genetic susceptibility to CD was not associated with anxiety. Genetic susceptibility to anxiety was not associated with UC or CD. No heterogeneity or pleiotropy was observed, and the leave-one-out analysis excluded the potential influence of a particular variant.
This study revealed that genetic susceptibility to UC was significantly associated with anxiety and highlighted the importance of early screening for anxiety in patients with UC. |
---|---|
Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Supported by China Postdoctoral Science Foundation, No. 2021M701614; Guangdong Basic and Applied Basic Research Foundation, No. 2022A1515111063 and No. 2022A1515111045; Foundation of Guangdong Provincial People’s Hospital, No. 8200010545. Author contributions: He Y, Chen CL and Liu SD proposed the study conception and designed the study methods; He Y, Chen CL and He J contributed to the data acquisition/analysis; He Y and He J contributed to the statistical analysis/interpretation; Liu SD supervised and managed the whole research process; He Y, Chen CL drafted the original manuscript; Liu SD reviewed and revised the original manuscript; all authors have read and approve the final manuscript. He Y and Chen CL contributed equally to this work; they were designated as co-first authors because they made equal and substantial contributions to the study conception, design, data analysis, and manuscript preparation and editing, each playing key roles in ensuring the integrity and quality of the manuscript. Co-first authors: Ying He and Chun-Lan Chen. Corresponding author: Si-De Liu, PhD, Professor, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, No. 1838 Guangzhou Avenue North, Guangzhou 510515, Guangdong Province, China. liuside2011@163.com |
ISSN: | 1007-9327 2219-2840 |
DOI: | 10.3748/wjg.v29.i44.5872 |