Caffeine impairs glucose metabolism in type 2 diabetes

• Published in: Diabetes care Vol. 27; no. 8; pp. 2047 - 2048
• Main Authors: LANE, James D, BARKAUSKAS, Christina E, SURWIT, Richard S, FEINGLOS, Mark N
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.08.2004
• Subjects: Beverages; Biological and medical sciences; Blood Glucose - drug effects; Blood Glucose - metabolism; Caffeine; Caffeine - pharmacology; Carbohydrates; Cross-Over Studies; Diabetes; Diabetes Mellitus, Type 2 - blood; Diabetes. Impaired glucose tolerance; Double-Blind Method; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Glucose; Humans; Insulin; Insulin - blood; Male; Medical sciences; Metabolism; Middle Aged; Placebos; Endocrinopathy; Type 2 diabetes; Human; Pancreatic hormone; CNS stimulant; Psychotropic; Glucose; Metabolism; Insulin; Respiratory analeptic; Protein hormone; Xanthine derivatives; Glycemia; Caffeine
• ISSN: 0149-5992; 1935-5548
• DOI: 10.2337/diacare.27.8.2047

Lane et al test how oral caffeine affects carbohydrate metabolism in patients with type 2 diabetes, for whom decreases in insulin sensitivity might result in exaggerate hyperglycemic responses to glucose and other carbohydrates, which would aggravate the glycemic dysregulation found in the disease. They also test the effects of caffeine on fasting glucose and insulin levels and on glucose and insulin responses to a mixed-meal tolerance test. Result shows that acute administration of caffeine impaired postprandial glucose metabolism in these diabetic patients. In contrast to nondiabetic subjects, their subjects demonstrated exaggerations of both glucose and insulin responses when caffeine was ingested with carbohydrates.