Use of a cyclo-oxygenase type-2-selective non-steroidal anti-inflammatory agent to prevent preterm delivery

Tocolytics and indometacin are commonly used to prevent pre-term deliveries, but have side-effects which are potentially life threatening to the mother or the fetus, inhibiting the cyclo-oxygenase (COX) enzyme which is upregulated in the fetus during labor. A COX-2-selective non-steroidal anti-infla...

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Bibliographic Details
Published inThe Lancet (British edition) Vol. 350; no. 9073; pp. 265 - 266
Main Authors Sawdy, Robert, Slater, Donna, Fisk, Nicholas, Edmonds, D Keith, Bennett, Phillip
Format Journal Article
LanguageEnglish
Published London Elsevier Ltd 26.07.1997
Lancet
Elsevier Limited
Subjects
Adult
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Biological and medical sciences
Cyclooxygenase 2
Cyclooxygenase 2 Inhibitors
Cyclooxygenase Inhibitors - therapeutic use
Drug therapy
Female
Genital system. Reproduction
Humans
Isoenzymes
Medical sciences
Membrane Proteins
Nonsteroidal anti-inflammatory drugs
Obstetric Labor, Premature - prevention & control
Pharmacology. Drug treatments
Pregnancy
Prostaglandin-Endoperoxide Synthases
Side effects
Sulfonamides - therapeutic use
Human
Premature
Prostaglandin-endoperoxide synthase
Enzyme
Treatment efficiency
Indometacin
Enzyme inhibitor
Maternal diseases
Tocolytic
Female genital diseases
Non steroidal antiinflammatory agent
Pregnancy
Case study
Prevention
Indoleacetic acid derivatives
Female
Oxidoreductases
Delivery
Pharmacokinetics
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Summary:Tocolytics and indometacin are commonly used to prevent pre-term deliveries, but have side-effects which are potentially life threatening to the mother or the fetus, inhibiting the cyclo-oxygenase (COX) enzyme which is upregulated in the fetus during labor. A COX-2-selective non-steroidal anti-inflammatory was studied in a 31-year-old woman who had lost eight previous pregnancies to preterm delivery, and the drug therapy assisted in the subject carrying a pregnancy to term with no harmful effect on the fetus.
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ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(05)62229-5