Vaccination as a triggering event for autoimmune hepatitis

The pathogenesis of autoimmune hepatitis entails complex interactions between triggering factors, autoantigens, genetic predisposition, and immunoregulatory networks. Implicated triggering factors are numerous and include toxins, medications, and infectious agents. In this article, we present a uniq...

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Bibliographic Details
Published inSeminars in liver disease Vol. 29; no. 3; p. 331
Main Authors Perumalswami, Ponni, Peng, Lan, Odin, Joseph A
Format Journal Article
LanguageEnglish
Published United States 01.08.2009
Subjects
Adult
Biomarkers - blood
Biopsy, Needle
Drug Therapy, Combination
Female
Hepatitis A Vaccines - adverse effects
Hepatitis, Autoimmune - diagnosis
Hepatitis, Autoimmune - drug therapy
Hepatitis, Autoimmune - etiology
Humans
Immunosuppressive Agents - therapeutic use
Liver - pathology
Treatment Outcome
Yellow Fever Vaccine - adverse effects
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Summary:The pathogenesis of autoimmune hepatitis entails complex interactions between triggering factors, autoantigens, genetic predisposition, and immunoregulatory networks. Implicated triggering factors are numerous and include toxins, medications, and infectious agents. In this article, we present a unique case of a 31-year-old woman with severe autoimmune hepatitis apparently abruptly triggered by vaccination. All evidence suggests this was an idiosyncratic response to either hepatitis A or yellow fever vaccination.
ISSN:1098-8971
DOI:10.1055/s-0029-1233537