Effect of magnesium sulfate on morphine activity retention to control pain after herniorrhaphy

• Published in: Pain management Vol. 7; no. 2; pp. 119 - 125
• Main Authors: Nadri, Sedigheh, Mahmoudvand, Hormoz, Vahabi, Sepideh
• Format: Journal Article
• Language: English
• Published: England Future Medicine Ltd 01.03.2017
• Subjects: Adolescent; Adult; Aged; Analgesics, Opioid - therapeutic use; Anesthesia; Bone surgery; Cardiovascular disease; Clinical trials; Defects; Double-Blind Method; Drug dosages; herniorrhaphy; Herniorrhaphy - adverse effects; Humans; Infertility; Magnesium; magnesium sulfate; Magnesium Sulfate - therapeutic use; Middle Aged; Morphine; Morphine - therapeutic use; Orthopedics; Pain; Pain management; Pain Measurement; Pain, Postoperative - drug therapy; Pain, Postoperative - etiology; Patients; Young Adult; Iran; herniorrhaphy; pain; magnesium sulfate; morphine
• ISSN: 1758-1869; 1758-1877
• DOI: 10.2217/pmt-2016-0038

This research was carried out to compare magnesium sulfate (MgSO ) with isotonic saline in terms of pain control after herniorrhaphy. A randomized double-blind study, in which the patients were blind to all. A total of 100 patients who were candidates of herniorrhaphy were randomized into two groups: experimental and control (50 patients in each). Anesthesia was induced with 20% of 4 cc of morphine. The experimental and control group received postoperative 20% of 2 cc MgSO in 2 cc of isotonic saline and 4 cc of isotonic saline, respectively. The administration of postoperative morphine in control group 0.79 ± 1.48 mg was significantly higher to the experimental group 0.17 ± 0.63 mg during the first 24 h (p = 0.01). MgSO increased the potency of morphine thereby reducing the amount of postoperative pain killer needed.