Concurrence of e1a2 and e19a2 BCR-ABL1 Fusion Transcripts in a Typical Case of Chronic Myeloid Leukemia
Dear Editor, There are three types of BCR-ABL1 fusion transcripts that differ on the basis of the breakpoint in the BCR gene [1]. The major type, encoding p210, has two isoforms, b2a2 (e13a2) and b3a2 (e14a2), and is associated with more than 95% of Ph-positive CML cases. The minor type, encoding p1...
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Published in | Annals of laboratory medicine Vol. 37; no. 1; pp. 74 - 76 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Korea (South)
The Korean Society for Laboratory Medicine
01.01.2017
대한진단검사의학회 |
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Abstract | Dear Editor, There are three types of BCR-ABL1 fusion transcripts that differ on the basis of the breakpoint in the BCR gene [1]. The major type, encoding p210, has two isoforms, b2a2 (e13a2) and b3a2 (e14a2), and is associated with more than 95% of Ph-positive CML cases. The minor type, encoding p190, is e1a2. The micro type, encoding p230, is e19a2. This micro type is rare, and has been associated with a variety of hematologic malignancies including neutrophilic CML (CML-N), all phases of classical CML, essential thrombocythemia (ET), and acute myeloid or lymphoblastic leukemia [2, 3]. Here, we describe the first case of chronic phase CML concurrently expressing e1a2 and e19a2 BCR-ABL1. KCI Citation Count: 1 |
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AbstractList | Dear Editor, There are three types of BCR-ABL1 fusion transcripts that differ on the basis of the breakpoint in the BCR gene [1]. The major type, encoding p210, has two isoforms, b2a2 (e13a2) and b3a2 (e14a2), and is associated with more than 95% of Ph-positive CML cases. The minor type, encoding p190, is e1a2. The micro type, encoding p230, is e19a2. This micro type is rare, and has been associated with a variety of hematologic malignancies including neutrophilic CML (CML-N), all phases of classical CML, essential thrombocythemia (ET), and acute myeloid or lymphoblastic leukemia [2, 3]. Here, we describe the first case of chronic phase CML concurrently expressing e1a2 and e19a2 BCR-ABL1. KCI Citation Count: 1 |
Author | Cho, Yong Gon Lee, Hye Soo Choi, Sam Im Lee, Jaehyeon Kim, Dal Sik |
AuthorAffiliation | 2 Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Korea 1 Department of Laboratory Medicine, Chonbuk National University Hospital, Jeonju, Korea |
AuthorAffiliation_xml | – name: 1 Department of Laboratory Medicine, Chonbuk National University Hospital, Jeonju, Korea – name: 2 Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Korea |
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Cites_doi | 10.1182/blood.V88.7.2410.bloodjournal8872410 10.1309/AJCPUN89CXERVOVH 10.1038/sj.leu.2401055 10.1038/leu.2010.265 10.1182/blood.V88.7.2375.bloodjournal8872375 10.1182/blood.V90.12.5024 10.1038/sj.leu.2402292 10.1182/blood-2009-07-234666 10.1182/blood.V87.12.5213.bloodjournal87125213 |
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References | 11753631 - Leukemia. 2001 Dec;15(12):2003-4 8839828 - Blood. 1996 Oct 1;88(7):2375-84 8839830 - Blood. 1996 Oct 1;88(7):2410-4 19605820 - Am J Clin Pathol. 2009 Aug;132(2):250-60 9389724 - Blood. 1997 Dec 15;90(12):5024-5 9665206 - Leukemia. 1998 Jul;12(7):1166-7 19833856 - Blood. 2009 Oct 15;114(16):3502-3 21072049 - Leukemia. 2011 Feb;25(2):366-7 8652835 - Blood. 1996 Jun 15;87(12):5213-7 Melo (10.3343/alm.2017.37.1.74_ref1) 1996; 88 Pane (10.3343/alm.2017.37.1.74_ref2) 1996; 88 How (10.3343/alm.2017.37.1.74_ref7) 1998; 12 Pardanani (10.3343/alm.2017.37.1.74_ref8) 2009; 114 Jeon (10.3343/alm.2017.37.1.74_ref3) 2011; 25 Bertorelle (10.3343/alm.2017.37.1.74_ref6) 2001; 15 Vardiman (10.3343/alm.2017.37.1.74_ref9) 2009; 132 van Rhee (10.3343/alm.2017.37.1.74_ref4) 1996; 87 Briz (10.3343/alm.2017.37.1.74_ref5) 1997; 90 |
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SubjectTerms | Aged, 80 and over Base Sequence Bone Marrow - pathology DNA - chemistry DNA - metabolism Female Fusion Proteins, bcr-abl - genetics Humans Letter to the Editor Leukemia, Myelogenous, Chronic, BCR-ABL Positive - diagnosis Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Multiplex Polymerase Chain Reaction Protein Isoforms - genetics Sequence Analysis, DNA 병리학 |
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Title | Concurrence of e1a2 and e19a2 BCR-ABL1 Fusion Transcripts in a Typical Case of Chronic Myeloid Leukemia |
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