Concurrence of e1a2 and e19a2 BCR-ABL1 Fusion Transcripts in a Typical Case of Chronic Myeloid Leukemia

• Published in: Annals of laboratory medicine Vol. 37; no. 1; pp. 74 - 76
• Main Authors: Lee, Jaehyeon, Kim, Dal Sik, Lee, Hye Soo, Choi, Sam Im, Cho, Yong Gon
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Society for Laboratory Medicine 01.01.2017; 대한진단검사의학회
• Subjects: Aged, 80 and over; Base Sequence; Bone Marrow - pathology; DNA - chemistry; DNA - metabolism; Female; Fusion Proteins, bcr-abl - genetics; Humans; Letter to the Editor; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - diagnosis; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics; Multiplex Polymerase Chain Reaction; Protein Isoforms - genetics; Sequence Analysis, DNA; 병리학
• ISSN: 2234-3806; 2234-3814
• DOI: 10.3343/alm.2017.37.1.74

Dear Editor, There are three types of BCR-ABL1 fusion transcripts that differ on the basis of the breakpoint in the BCR gene [1]. The major type, encoding p210, has two isoforms, b2a2 (e13a2) and b3a2 (e14a2), and is associated with more than 95% of Ph-positive CML cases. The minor type, encoding p190, is e1a2. The micro type, encoding p230, is e19a2. This micro type is rare, and has been associated with a variety of hematologic malignancies including neutrophilic CML (CML-N), all phases of classical CML, essential thrombocythemia (ET), and acute myeloid or lymphoblastic leukemia [2, 3]. Here, we describe the first case of chronic phase CML concurrently expressing e1a2 and e19a2 BCR-ABL1. KCI Citation Count: 1