Short-Term Elevation of Fine Particulate Matter Air Pollution and Acute Lower Respiratory Infection

• Published in: American journal of respiratory and critical care medicine Vol. 198; no. 6; pp. 759 - 766
• Main Authors: Horne, Benjamin D., Joy, Elizabeth A., Hofmann, Michelle G., Gesteland, Per H., Cannon, John B., Lefler, Jacob S., Blagev, Denitza P., Korgenski, E. Kent, Torosyan, Natalie, Hansen, Grant I., Kartchner, David, Pope, C. Arden
• Format: Journal Article
• Language: English
• Published: United States American Thoracic Society 15.09.2018
• Subjects: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Air pollution; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Inhalation Exposure - adverse effects; Male; Middle Aged; Mortality; Outdoor air quality; Particulate Matter - adverse effects; Quinones; Respiratory syncytial virus; Respiratory Tract Infections - epidemiology; Respiratory Tract Infections - etiology; Viral infections; Weather; Young Adult; United States > US; Utah; bronchitis; influenza virus; respiratory syncytial virus; bronchiolitis; PM2.5
• ISSN: 1073-449X; 1535-4970; 1535-4970
• DOI: 10.1164/rccm.201709-1883OC

Nearly 60% of U.S. children live in counties with particulate matter less than or equal to 2.5 μm in aerodynamic diameter (PM ) concentrations above air quality standards. Understanding the relationship between ambient air pollution exposure and health outcomes informs actions to reduce exposure and disease risk. To evaluate the association between ambient PM levels and healthcare encounters for acute lower respiratory infection (ALRI). Using an observational case-crossover design, subjects (n = 146,397) were studied if they had an ALRI diagnosis and resided on Utah's Wasatch Front. PM air pollution concentrations were measured using community-based air quality monitors between 1999 and 2016. Odds ratios for ALRI healthcare encounters were calculated after stratification by ages 0-2, 3-17, and 18 or more years. Approximately 77% (n = 112,467) of subjects were 0-2 years of age. The odds of ALRI encounter for these young children increased within 1 week of elevated PM and peaked after 3 weeks with a cumulative 28-day odds ratio of 1.15 per +10 μg/m (95% confidence interval, 1.12-1.19). ALRI encounters with diagnosed and laboratory-confirmed respiratory syncytial virus and influenza increased following elevated ambient PM levels. Similar elevated odds for ALRI were also observed for older children, although the number of events and precision of estimates were much lower. In this large sample of urban/suburban patients, short-term exposure to elevated PM air pollution was associated with greater healthcare use for ALRI in young children, older children, and adults. Further exploration is needed of causal interactions between PM and ALRI.