Dependence of oxalate absorption on the daily calcium intake

Two to 20% of ingested oxalate is absorbed in the gastrointestinal tract of healthy humans with a daily 800 mg calcium intake. Calcium is the most potent modifier of the oxalate absorption. Although this has been found repeatedly, the exact correlation between calcium intake and oxalate absorption h...

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Published inJournal of the American Society of Nephrology Vol. 15; no. 6; pp. 1567 - 1573
Main Authors VON UNRUH, Gerd E, VOSS, Susanne, SAUERBRUCH, Tilman, HESSE, Albrecht
Format Journal Article
LanguageEnglish
Published Hagerstown, MD Lippincott Williams & Wilkins 01.06.2004
Subjects
Absorption
Adult
Animals
Biological and medical sciences
Calcium Oxalate - metabolism
Calcium, Dietary - metabolism
Calcium, Dietary - urine
Dietary Supplements
Dose-Response Relationship, Drug
Female
Food
Humans
Magnesium - urine
Male
Medical sciences
Middle Aged
Milk
Nephrology. Urinary tract diseases
Urinary Calculi - prevention & control
Daily
Nephrology
Absorption
Calcium
Oxalate
Dependence
Inorganic element
Urology
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Summary:Two to 20% of ingested oxalate is absorbed in the gastrointestinal tract of healthy humans with a daily 800 mg calcium intake. Calcium is the most potent modifier of the oxalate absorption. Although this has been found repeatedly, the exact correlation between calcium intake and oxalate absorption has not been assessed to date. Investigated was oxalate absorption in healthy volunteers applying 0.37 mmol of the soluble salt sodium [(13)C(2)]oxalate in the calcium intake range from 5 mmol (200 mg) calcium to 45 mmol (1800 mg) calcium. Within the range of 200 to 1200 mg calcium per day, oxalate absorption depended linearly on the calcium intake. With 200 mg calcium per day, the mean absorption (+/- SD) was 17% +/- 8.3%; with 1200 mg calcium per day, the mean absorption was 2.6% +/- 1.5%. Within this range, reduction of the calcium supply by 70 mg increased the oxalate absorption by 1% and vice versa. Calcium addition beyond 1200 mg/d reduced the oxalate absorption only one-tenth as effectively. With 1800 mg calcium per day, the mean absorption was 1.7% +/- 0.9%. The findings may explain why a low-calcium diet increases the risk of calcium oxalate stone formation.
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ISSN:1046-6673
1533-3450
DOI:10.1097/01.ASN.0000127864.26968.7F