Neuronal Circuits in Barrel Cortex for Whisker Sensory Perception

• Published in: Physiological reviews Vol. 101; no. 1; pp. 353 - 415
• Main Authors: Staiger, Jochen F, Petersen, Carl C H
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.01.2021
• Subjects: Animals; Brain Diseases - physiopathology; Brain-Computer Interfaces; Cortex (barrel); Cortex (somatosensory); Decision making; Humans; Information processing; Mice; Neural networks; Neural Pathways - physiology; Neuromodulation; Sensation - physiology; Sensory integration; Signal Transduction - physiology; Somatosensory Cortex - physiology; Vibrissae; Vibrissae - innervation; Vibrissae - physiology; barrel cortex; sensory perception; principal cells; synaptic circuits; GABAergic neurons
• ISSN: 0031-9333; 1522-1210
• DOI: 10.1152/physrev.00019.2019

The array of whiskers on the snout provides rodents with tactile sensory information relating to the size, shape and texture of objects in their immediate environment. Rodents can use their whiskers to detect stimuli, distinguish textures, locate objects and navigate. Important aspects of whisker sensation are thought to result from neuronal computations in the whisker somatosensory cortex (wS1). Each whisker is individually represented in the somatotopic map of wS1 by an anatomical unit named a 'barrel' (hence also called barrel cortex). This allows precise investigation of sensory processing in the context of a well-defined map. Here, we first review the signaling pathways from the whiskers to wS1, and then discuss current understanding of the various types of excitatory and inhibitory neurons present within wS1. Different classes of cells can be defined according to anatomical, electrophysiological and molecular features. The synaptic connectivity of neurons within local wS1 microcircuits, as well as their long-range interactions and the impact of neuromodulators, are beginning to be understood. Recent technological progress has allowed cell-type-specific connectivity to be related to cell-type-specific activity during whisker-related behaviors. An important goal for future research is to obtain a causal and mechanistic understanding of how selected aspects of tactile sensory information are processed by specific types of neurons in the synaptically connected neuronal networks of wS1 and signaled to downstream brain areas, thus contributing to sensory-guided decision-making.