Review of the structural and functional brain changes associated with chronic kidney disease

Chronic kidney disease (CKD) leads to profound metabolic and hemodynamic changes, which damage other organs, such as heart and brain. The brain abnormalities and cognitive deficit progress with the severity of the CKD and are mostly expressed among hemodialysis patients. They have great socio-econom...

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Published inPhysiological research Vol. 69; no. 6; pp. 1013 - 1028
Main Authors Michna, M, Kovarova, L, Valerianova, A, Malikova, H, Weichet, J, Malik, J
Format Journal Article
LanguageEnglish
Published Czech Republic Institute of Physiology 22.12.2020
Institute of Physiology of the Czech Academy of Sciences
Subjects
Age
Alzheimer's disease
Animals
Brain - diagnostic imaging
Brain - pathology
Cognition & reasoning
Cognition Disorders - etiology
Cognition Disorders - pathology
Cognitive ability
Dementia
Diabetes
Hemodialysis
Humans
Huntingtons disease
Hypertension
Kidney diseases
Metabolism
Metabolites
Mortality
Parkinson's disease
Patients
Peritoneal dialysis
Population
Renal Insufficiency, Chronic - complications
Renal Insufficiency, Chronic - pathology
Renal replacement therapy
Review
Risk Factors
Structure-function relationships
Toxins
Transplants & implants
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Summary:Chronic kidney disease (CKD) leads to profound metabolic and hemodynamic changes, which damage other organs, such as heart and brain. The brain abnormalities and cognitive deficit progress with the severity of the CKD and are mostly expressed among hemodialysis patients. They have great socio-economic impact. In this review, we present the current knowledge of involved mechanisms.
ISSN:0862-8408
1802-9973
DOI:10.33549/physiolres.934420