Quercetin: a mutagen, not a carcinogen, in Fischer rats

Purified quercetin, as well as diets containing quercetin at 0.1% and 0.2%, are mutagens to Salmonella typhimurium TA100. This mutagenicity is enhanced with the S9 metabolic activation system. The urine of Fischer rats fed the 0.2% quercetin diet also is mutagenic with the S9 activation system, but...

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Published inJournal of toxicology and environmental health Vol. 14; no. 2/3; p. 105
Main Authors Stoewsand, G.S, Anderson, J.L, Boyd, J.N, Hrazdina, G, Babish, J.G, Walsh, K.M, Losco, P
Format Journal Article
LanguageEnglish
Published United States 1984
Subjects
Animals
Feces
Female
FLAVONOIDE
FLAVONOIDES
FLAVONOIDS
Flavonoids - toxicity
Male
MUTAGENE
MUTAGENOS
MUTAGENS
Mutagens - metabolism
Neoplasms, Experimental - chemically induced
QUERCETIN
Quercetin - toxicity
RAT
RATA
RATS
Rats, Inbred F344
Reproduction - drug effects
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Summary:Purified quercetin, as well as diets containing quercetin at 0.1% and 0.2%, are mutagens to Salmonella typhimurium TA100. This mutagenicity is enhanced with the S9 metabolic activation system. The urine of Fischer rats fed the 0.2% quercetin diet also is mutagenic with the S9 activation system, but the feces of these animals exhibited enhanced mutagenicity only without activation. This may indicate different quercetin metabolites in urine and feces. Rats fed these diets for 64 wk showed no consistent tissue lesions, carcinogenicity, or reproductive changes. Male rats fed 0.2% quercetin showed lowered blood serum glutamic oxaloacetic transaminase and urea nitrogen levels, but these values do not reflect pathological changes.
Bibliography:Q03
8617702
ISSN:0098-4108
1087-2620
DOI:10.1080/15287398409530565