The biokinetics and radiotoxicology of curium: A comparison with americium

The human and animal data on the biokinetics of 242Cm and 244Cm are reviewed and shown to be very similar to those for 241Am. Liver and skeleton are the main organs of deposition and the retention of curium in the skeleton is very prolonged in all the species examined. Retention of both curium and a...

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Bibliographic Details
Published inApplied radiation and isotopes Vol. 66; no. 5; pp. 632 - 647
Main Authors Ménétrier, F., Taylor, D.M., Comte, A.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.05.2008
Subjects
Americium - pharmacokinetics
Americium - toxicity
Animals
Biodistribution
Biokinetics
Chelation therapy
Curium - pharmacokinetics
Curium - toxicity
Curium isotopes
Female
Humans
Maternal-Fetal Exchange
Pregnancy
Tissue Distribution
Toxicity
Biokinetics
Curium isotopes
Toxicity
Biodistribution
Chelation therapy
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Summary:The human and animal data on the biokinetics of 242Cm and 244Cm are reviewed and shown to be very similar to those for 241Am. Liver and skeleton are the main organs of deposition and the retention of curium in the skeleton is very prolonged in all the species examined. Retention of both curium and americium in the liver appears to be species-dependent, being relatively rapidly removed from the liver of rats, and probably humans, but being tenaciously retained in dogs and some other species. The radiotoxicity of curium is also reviewed and it is shown that, as with 241Am, lung and bone tumour induction are the major hazards from inhaled and systemically deposited 244Cm. The use of chelating agents for the treatment of accidental contamination of the human body with 242,244Cm is also discussed.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0969-8043
1872-9800
DOI:10.1016/j.apradiso.2007.12.002