New N-Mannich bases obtained from isatin and piperazine derivatives: the synthesis and evaluation of antimicrobial activity

A Mannich reaction of isatin with monosubstituted piperazines in the presence of aqueous formaldehyde was used to synthesize new, as well as two previously described derivatives of 1-piperazinomethylisatins, which were further converted to isoindigo derivatives. The antimicrobial activity of the obt...

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Published inChemistry of heterocyclic compounds (New York, N.Y. 1965) Vol. 52; no. 1; pp. 25 - 30
Main Authors Bogdanov, Andrei V., Vazykhova, Al’bina M., Khasiyatullina, Nadezhda R., Krivolapov, Dmitry B., Dobrynin, Alexey B., Voloshina, Alexandra D., Mironov, Vladimir F.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.01.2016
Springer Nature
Springer
Subjects
Chemistry
Chemistry and Materials Science
Chemistry, Organic
Formaldehyde
Nitrogen (Chemical element)
Organic Chemistry
Pharmacy
Physical Sciences
Science & Technology
piperazines
antimicrobial activity
aminomethylation
isatin
Mannich reaction
DESIGN
ANTIBACTERIAL
ANTIFUNGAL ACTIVITIES
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Summary:A Mannich reaction of isatin with monosubstituted piperazines in the presence of aqueous formaldehyde was used to synthesize new, as well as two previously described derivatives of 1-piperazinomethylisatins, which were further converted to isoindigo derivatives. The antimicrobial activity of the obtained heterocycles was evaluated.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-016-1826-6