Amygdala subfield and prefrontal cortex abnormalities in patients with functional seizures

• Published in: Epilepsy & behavior Vol. 145; p. 109278
• Main Authors: Nasrullah, Nilab, Kerr, Wesley T., Stern, John M., Wang, Yanlu, Tatekawa, Hiroyuki, Lee, John K., Karimi, Amir H., Sreenivasan, Siddhika S., Engel, Jerome, Eliashiv, Dawn E., Feusner, Jamie D., Salamon, Noriko, Savic, Ivanka
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2023
• Subjects: Amygdala; Chronic stress; Cortical thickness; Hippocampus; Medicin och hälsovetenskap; Psychogenic nonepileptic seizures; Psychogenic nonepileptic seizures; Chronic stress; Cortical thickness; Amygdala; Hippocampus
• ISSN: 1525-5050; 1525-5069; 1525-5069
• DOI: 10.1016/j.yebeh.2023.109278

•Structural MRIs for 37 female patients with FS were compared to 37 age-matched female seizure naïve controls.•Differences were seen in the lateral, central, and medial nucleus of the amygdala.•Thinning of the prefrontal and motor cortex was detected in patients with FS.•The cerebral regions associated with FS co-localized with typical findings of chronic stress conditions. Functional seizures (FS) are paroxysmal episodes, resembling epileptic seizures, but without underlying epileptic abnormality. The aetiology and neuroanatomic associations are incompletely understood. Recent brain imaging data indicate cerebral changes, however, without clarifying possible pathophysiology. In the present study, we specifically investigated the neuroanatomic changes in subregions of the amygdala and hippocampus in FS. T1 MRI scans of 37 female patients with FS and 37 age-matched female seizure naïve controls (SNC) were analyzed retrospectively in FreeSurfer version 7.1. Seizure naïve controls included patients with depression and anxiety disorders. The analysis included whole-brain cortical thickness, subcortical volumes, and subfields of the amygdala and hippocampus. Group comparisons were carried out using multivariable linear models. The FS and SNC groups did not differ in the whole hippocampus and amygdala volumes. However, patients had a significant reduction of the right lateral amygdala volume (p = 0.00041), an increase of the right central amygdala, (p = 0.037), and thinning of the left superior frontal gyrus (p = 0.024). Additional findings in patients were increased volumes of the right medial amygdala (p = 0.031), left anterior amygdala (p = 0.017), and left dentate gyrus of the hippocampus (p = 0.035). The observations from the amygdala and hippocampus segmentation affirm that there are neuroanatomic associations of FS. The pattern of these changes aligned with some of the cerebral changes described in chronic stress conditions and depression. The pattern of detected changes further study, and may, after validation, provide biomarkers for diagnosis and treatment.