The Impact of Metabolic Syndrome on Heart Failure in Young Korean Population: A Nationwide Study

Limited data are available regarding the effect of metabolic syndrome on heart failure (HF) development in young individuals. Utilizing data from the Korean National Health Insurance Service, we included a total of 1,958,284 subjects in their 40s who underwent health screening between January 2009 a...

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Published inMetabolites Vol. 14; no. 9; p. 485
Main Authors Kim, Tae-Eun, Kim, Do Young, Kim, Hyeongsu, Sung, Jidong, Kim, Duk-Kyung, Lee, Myoung-Soon, Han, Seong Woo, Kim, Hyun-Joong, Ki, Hyun Kyun, Kim, Sung Hea, Ryu, Kyu-Hyung
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 04.09.2024
MDPI
Subjects
Body mass index
Cardiovascular disease
Cholesterol
Codes
Congestive heart failure
Creatinine
Demographics
Diabetes
Exercise
Females
Health insurance
Heart attack
Heart attacks
Heart failure
Hemoglobin
Hypertension
Males
Medical screening
Metabolic syndrome
Myocardial infarction
National health insurance
Population studies
Population-based studies
Risk factors
Smoking
Triglycerides
Variables
Womens health
young age
South Korea
metabolic syndrome
heart failure
young age
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Summary:Limited data are available regarding the effect of metabolic syndrome on heart failure (HF) development in young individuals. Utilizing data from the Korean National Health Insurance Service, we included a total of 1,958,284 subjects in their 40s who underwent health screening between January 2009 and December 2009 in Korea. Subjects were classified into three groups: normal, pre-metabolic syndrome (Pre-MetS), and metabolic syndrome (MetS). MetS was identified in 10.58% of males and 5.21% of females. The hazard ratio for HF in subjects with MetS was 1.968 (95% CI: 1.526-2.539) for males and 2.398 (95% CI: 1.466-3.923) for females. For those with Pre-MetS, the hazard ratio was 1.607 (95% CI: 1.293-1.997) in males and 1.893 (95% CI: 1.43-2.505) in females. Additionally, acute myocardial infarction and low hemoglobin levels were identified as significant risk factors for HF in both genders. MetS approximately doubled the risk of developing HF in individuals in their 40s. Pre-MetS was also a significant risk factor for HF in this population.
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These authors contributed equally to this work.
ISSN:2218-1989
2218-1989
DOI:10.3390/metabo14090485