New dibenzocyclooctadiene lignan from Schisandra chinensis (Turcz.) Baill. fruits

Repeated column chromatography using Sephadex LH-20, silica gel (SiO 2 ), and octadecyl SiO 2 (ODS) as well as preparative HPLC column chromatography led to isolation of a new dibenzocyclooctadiene lignan along with four known ones, gomisin L2 ( 1 ), L1 ( 2 ), M1 ( 3 ), and M2 ( 4 ). Their chemical...

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Published inApplied biological chemistry Vol. 64; no. 1; pp. 1 - 6
Main Authors Nguyen, Trong Nguyen, Lee, Yeong-Geun, Kim, Hyoung-Geun, Yoon, Dahye, Jeong, Jin Tae, Lee, Dae Young, Baek, Nam-In
Format Journal Article
LanguageEnglish
Published Singapore Springer Singapore 01.12.2021
Springer Nature B.V
한국응용생명화학회
Subjects
Absolute configuration
Applied Microbiology
Biological Techniques
Bioorganic Chemistry
Chemistry
Chemistry and Materials Science
Chirality
Chromatography
Column chromatography
High performance liquid chromatography
Lignans
Liquid chromatography
Margarine
NMR
Nuclear magnetic resonance
Silica
Silica gel
Silicon dioxide
Stereochemistry
농학
Gomisin M3
Atropisomer
Axial chirality
Circular dichroism
Dibenzocyclooctadiene lignan
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Summary:Repeated column chromatography using Sephadex LH-20, silica gel (SiO 2 ), and octadecyl SiO 2 (ODS) as well as preparative HPLC column chromatography led to isolation of a new dibenzocyclooctadiene lignan along with four known ones, gomisin L2 ( 1 ), L1 ( 2 ), M1 ( 3 ), and M2 ( 4 ). Their chemical structures were fixed based on MS, IR, and NMR data analyses. In addition, the stereochemistry of atropisomers, the absolute configuration of the axial chirality in a biphenyl structure, was confirmed by a CD experiment. The new lignan was named gomisin M3 ( 5 ).
ISSN:2468-0834
2468-0842
DOI:10.1186/s13765-021-00618-1