Cyclobutanes from Combretum albopunctatum

• Published in: Phytochemistry (Oxford) Vol. 65; no. 4; pp. 433 - 438
• Main Authors: Katerere, David R, Gray, Alexander I, Kennedy, Alan R, Nash, Robert J, Waigh, Roger D
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 01.02.2004; Elsevier
• Subjects: Biochemistry & Molecular Biology; Biological and medical sciences; Chalcone - analogs & derivatives; Chalcone - isolation & purification; Chalcones; Chemical constitution; Combretaceae; Combretum - chemistry; Combretum albopunctatum; Cyclobutanes - chemistry; Cyclobutanes - isolation & purification; Dimerization; Flavanones Chalcone dimer; Flavonoids; Fundamental and applied biological sciences. Psychology; Life Sciences & Biomedicine; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plant Components, Aerial - chemistry; Plant Extracts - chemistry; Plant physiology and development; Plant Sciences; Science & Technology; Stereoisomerism; X-Ray Diffraction; Combretum albopunctatum; Flavonoids; Chalcones; Combretaceae; Flavanones Chalcone dimer; chalcones; ACID; flavonoids; flavanones chalcone dimer; Molecular structure; Chemical structure; Flavonoid; Chalcone; Dicotyledones; Cyclobutane derivatives; Angiospermae; Phenols; Above ground plant part; Spermatophyta; Dimer
• ISSN: 0031-9422; 1873-3700
• DOI: 10.1016/j.phytochem.2003.09.014

A dichloromethane extract of the aerial parts of Combretum albopunctatum Suesseng afforded five phenolic compounds—three known flavonoids and two novel cyclobutane chalcone dimers. The chemical structures were determined by standard spectroscopic techniques and the structure and relative stereochemistry of one chalcone dimer, rel-(1α,2β)-di-(2,6-dimethoxy-4-hydroxy)-benzoyl- rel-(3α,4β)-diphenylcyclobutane, were confirmed by single crystal X-ray diffraction. Two new cyclobutane chalcone dimers have been isolated from the aerial parts of C. albopunctatum.