Detrended fluctuation analysis of cerebrovascular responses to abrupt changes in peripheral arterial pressure in rats

• Published in: Communications in nonlinear science & numerical simulation Vol. 85; p. 105232
• Main Authors: Pavlov, A.N., Abdurashitov, A.S., Koronovskii, A.A., Pavlova, O.N., Semyachkina-Glushkovskaya, O.V., Kurths, J.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.06.2020; Elsevier Science Ltd
• Subjects: Blood circulation; Blood flow; Blood pressure; Blood vessels; Capillaries; Cerebral blood flow; Detrended fluctuation analysis; Laser speckle contrast imaging; Multifractality; Rodents; Scaling exponent; Statistical analysis; Studies; Vein & artery diseases; Veins; Veins & arteries; Detrended fluctuation analysis; Scaling exponent; Multifractality; Cerebral blood flow; Laser speckle contrast imaging
• ISSN: 1007-5704; 1878-7274
• DOI: 10.1016/j.cnsns.2020.105232

•Reactions of cerebral blood circulation to ”jumps” in peripheral arterial pressure are studied.•An extension of the conventional DFA approach is proposed.•Significant distinctions in the responses of cerebral blood vessels are reported. We study scaling features in the reactions of cereral blood vessel network to sudden “jumps” in peripheral arterial pressure in rats. Using laser speckle contrast imaging (LSCI) to measure the relative velocity of cerebral blood flow (CBF) and detrended fluctuation analysis (DFA) for processing experimental data, we investigate distinctions in the responses of veins and capillaries. To quantify short-term reactions associated with transients, we propose an extension of the conventional DFA approach, which estimates an additional scaling exponent reflecting the effect of nonstationarity. We also consider the ability of characterizing vascular dynamics with multifractal DFA in terms of the degree of multiscality. Based on statistical analysis, we report significant distinctions in the responses of small network of microcerebral blood vessels compared to veins such as the sagittal sinus, which are quite insensitive to variations in peripheral blood circulation.