Trabecular Bone Structures in the Edentulous Diastema of Osteoporotic Sheep

The edentulous ovine diastema represents a suitable region for implantological research. Due to distinctive embryonic origin and mechanical loading, the edentulous diastema may respond differently to osteoporosis than tooth-bearing areas. To test this assumption, we subjected geriatric sheep to ovar...

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Bibliographic Details
Published inJournal of dental research Vol. 87; no. 9; pp. 866 - 870
Main Authors Dvorak, G., Gruber, R., Huber, C.D., Goldhahn, J., Zanoni, G., Salaberger, D., Watzek, G., Haas, R.
Format Journal Article
LanguageEnglish
Published United States SAGE Publications 01.09.2008
SAGE PUBLICATIONS, INC
Subjects
Aging - physiology
Animals
Bone Density - physiology
Diastema
Disease Models, Animal
Female
Jaw, Edentulous, Partially - pathology
Maxilla - pathology
Maxilla - physiology
Osteoporosis - chemically induced
Osteoporosis - pathology
Osteoporosis - physiopathology
Sheep
Weight-Bearing
μCT
osteoporosis
trabecular bone
maxilla
sheep
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Summary:The edentulous ovine diastema represents a suitable region for implantological research. Due to distinctive embryonic origin and mechanical loading, the edentulous diastema may respond differently to osteoporosis than tooth-bearing areas. To test this assumption, we subjected geriatric sheep to ovariectomy, calcium-/vitamin-D-restricted diet, and methylprednisolone administration. Adult control sheep remained untreated. Structural parameters and bone mineral density were determined by microcomputed tomography and conventional computed tomography, respectively. We report that the trabecular microstructure in the diastema was preserved from catabolic changes. In contrast, the premolar maxillary region of osteoporotic sheep had diminished trabecular bone mineral density, with the corresponding structural deteriorations. These results suggest that maxillary trabecular bone of the edentulous diastema does not respond to catabolic changes which occur in the tooth-bearing area in osteoporosis. Our findings imply that regional anatomic domains must be considered in the planning of pre-clinical studies, taking osteoporotic changes into account.
ISSN:0022-0345
1544-0591
DOI:10.1177/154405910808700918