NMDA Receptor Gating of Information Flow through the Striatum In Vivo

A role of NMDA receptors in corticostriatal synaptic plasticity is widely acknowledged. However, the conditions that allow NMDA receptor activation in the striatum in vivo remain obscure. Here we show that NMDA receptors contribute to sustain the membrane potential of striatal medium spiny projectio...

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Published inThe Journal of neuroscience Vol. 28; no. 50; pp. 13384 - 13389
Main Authors Pomata, Pablo E, Belluscio, Mariano A, Riquelme, Luis A, Murer, M. Gustavo
Format Journal Article
LanguageEnglish
Published United States Soc Neuroscience 10.12.2008
Society for Neuroscience
Subjects
Animals
Brief Communications
Corpus Striatum - physiology
Ion Channel Gating - physiology
Learning - physiology
Male
Membrane Potentials - physiology
Microdialysis
Neurons - metabolism
Rats
Rats, Sprague-Dawley
Receptors, N-Methyl-D-Aspartate - metabolism
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Summary:A role of NMDA receptors in corticostriatal synaptic plasticity is widely acknowledged. However, the conditions that allow NMDA receptor activation in the striatum in vivo remain obscure. Here we show that NMDA receptors contribute to sustain the membrane potential of striatal medium spiny projection neurons close to threshold during spontaneous UP states in vivo. Moreover, we found that the blockade of striatal NMDA receptors reduces markedly the spontaneous firing of ensembles of medium spiny neurons during slow waves in urethane-anesthetized rats. We speculate that recurrent activation of NMDA receptors during UP states allows off-line information flow through the striatum and system level consolidation during habit formation.
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ISSN:0270-6474
1529-2401
1529-2401
DOI:10.1523/JNEUROSCI.4343-08.2008