An iron-oxygen intermediate formed during the catalytic cycle of cysteine dioxygenase

Cysteine dioxygenase is a key enzyme in the breakdown of cysteine, but its mechanism remains controversial. A combination of spectroscopic and computational studies provides the first evidence of a short-lived intermediate in the catalytic cycle. The intermediate decays within 20 ms and has absorpti...

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 52; no. 57; pp. 8814 - 8817
Main Authors Tchesnokov, E P, Faponle, A S, Davies, C G, Quesne, M G, Turner, R, Fellner, M, Souness, R J, Wilbanks, S M, de Visser, S P, Jameson, G N L
Format Journal Article
LanguageEnglish
Published England 01.01.2016
Subjects
Absorption
Breakdown
Catalysis
Catalysts
Cysteine
Decay
Maxima
Spectroscopy
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Summary:Cysteine dioxygenase is a key enzyme in the breakdown of cysteine, but its mechanism remains controversial. A combination of spectroscopic and computational studies provides the first evidence of a short-lived intermediate in the catalytic cycle. The intermediate decays within 20 ms and has absorption maxima at 500 and 640 nm.
Bibliography:ObjectType-Article-1
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ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc03904a