Nephrogenic systemic fibrosis: a case series suggesting gadolinium as a possible aetiological factor

• Published in: British journal of dermatology (1951) Vol. 157; no. 4; pp. 783 - 787
• Main Authors: Moreno‐Romero, J.A., Segura, S., Mascaró, J.M., Cowper, S.E., Julià, M., Poch, E., Botey, A., Herrero, C.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.10.2007; Blackwell
• Subjects: Adult; Aged; Biological and medical sciences; Contrast Media - adverse effects; Dermatology; Drug Eruptions - etiology; Drug Eruptions - pathology; Female; Fibrosis - chemically induced; gadolinium; Gadolinium DTPA - adverse effects; Humans; Hyperpigmentation - chemically induced; Hyperpigmentation - pathology; Magnetic Resonance Angiography - adverse effects; Male; Medical sciences; Middle Aged; nephrogenic fibrosing dermopathy; nephrogenic systemic fibrosis; Nephrology. Urinary tract diseases; Nephropathies. Renovascular diseases. Renal failure; Renal failure; Renal Insufficiency - complications; Renal Insufficiency - diagnosis; Skin - pathology; Kidney disease; Skin disease; Urinary system disease; Nephrogenic fibrosing dermopathy; Dermatology; Etiology; Renal failure; nephrogenic systemic fibrosis; gadolinium
• ISSN: 0007-0963; 1365-2133
• DOI: 10.1111/j.1365-2133.2007.08067.x

Summary Nephrogenic systemic fibrosis (NSF) or nephrogenic fibrosing dermopathy is a rare fibrotic condition that presents in patients with a history of renal disease. The aetiology is unknown, but it has recently been proposed that gadolinium, a paramagnetic contrast agent, may be a trigger of this disease. We report three patients with NSF with a history of use of gadolinium in magnetic resonance angiography a few weeks before the onset of symptoms. In the future, gadolinium should probably be avoided as much as possible in renal insufficiency patients until its role in the development of NSF is clarified.