Enhanced peripheral nerve regeneration through asymmetrically porous nerve guide conduit with nerve growth factor gradient
In this study, we fabricated a nerve guide conduit (NGC) with nerve growth factor (NGF) gradient along the longitudinal direction by rolling a porous polycaprolactone membrane with NGF concentration gradient. The NGF immobilized on the membrane was continuously released for up to 35 days, and the re...
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| Published in | Journal of biomedical materials research. Part A Vol. 106; no. 1; pp. 52 - 64 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
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01.01.2018
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| Abstract | In this study, we fabricated a nerve guide conduit (NGC) with nerve growth factor (NGF) gradient along the longitudinal direction by rolling a porous polycaprolactone membrane with NGF concentration gradient. The NGF immobilized on the membrane was continuously released for up to 35 days, and the released amount of the NGF from the membrane gradually increased from the proximal to distal NGF ends, which may allow a neurotrophic factor gradient in the tubular NGC for a sufficient period. From the in vitro cell culture experiment, it was observed that the PC12 cells sense the NGF concentration gradient on the membrane for the cell proliferation and differentiation. From the in vivo animal experiment using a long gap (20 mm) sciatic nerve defect model of rats, the NGC with NGF concentration gradient allowed more rapid nerve regeneration through the NGC than the NGC itself and NGC immobilized with uniformly distributed NGF. The NGC with NGF concentration gradient seems to be a promising strategy for the peripheral nerve regeneration. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 52–64, 2018. |
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| AbstractList | Abstract
In this study, we fabricated a nerve guide conduit (NGC) with nerve growth factor (NGF) gradient along the longitudinal direction by rolling a porous polycaprolactone membrane with NGF concentration gradient. The NGF immobilized on the membrane was continuously released for up to 35 days, and the released amount of the NGF from the membrane gradually increased from the proximal to distal NGF ends, which may allow a neurotrophic factor gradient in the tubular NGC for a sufficient period. From the
in vitro
cell culture experiment, it was observed that the PC12 cells sense the NGF concentration gradient on the membrane for the cell proliferation and differentiation. From the
in vivo
animal experiment using a long gap (20 mm) sciatic nerve defect model of rats, the NGC with NGF concentration gradient allowed more rapid nerve regeneration through the NGC than the NGC itself and NGC immobilized with uniformly distributed NGF. The NGC with NGF concentration gradient seems to be a promising strategy for the peripheral nerve regeneration. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 52–64, 2018. In this study, we fabricated a nerve guide conduit (NGC) with nerve growth factor (NGF) gradient along the longitudinal direction by rolling a porous polycaprolactone membrane with NGF concentration gradient. The NGF immobilized on the membrane was continuously released for up to 35 days, and the released amount of the NGF from the membrane gradually increased from the proximal to distal NGF ends, which may allow a neurotrophic factor gradient in the tubular NGC for a sufficient period. From the in vitro cell culture experiment, it was observed that the PC12 cells sense the NGF concentration gradient on the membrane for the cell proliferation and differentiation. From the in vivo animal experiment using a long gap (20 mm) sciatic nerve defect model of rats, the NGC with NGF concentration gradient allowed more rapid nerve regeneration through the NGC than the NGC itself and NGC immobilized with uniformly distributed NGF. The NGC with NGF concentration gradient seems to be a promising strategy for the peripheral nerve regeneration. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 52-64, 2018. |
| Author | Song, Kyu Sang Lee, Jin Ho Oh, Se Heang Namgung, Uk Kim, Tae Ho Kang, Jun Goo Jeon, Byeong Hwa |
| Author_xml | – sequence: 1 givenname: Se Heang surname: Oh fullname: Oh, Se Heang organization: Dankook University – sequence: 2 givenname: Jun Goo surname: Kang fullname: Kang, Jun Goo organization: Hannam University – sequence: 3 givenname: Tae Ho surname: Kim fullname: Kim, Tae Ho organization: Hannam University – sequence: 4 givenname: Uk surname: Namgung fullname: Namgung, Uk organization: Daejeon University – sequence: 5 givenname: Kyu Sang surname: Song fullname: Song, Kyu Sang organization: Chungnam National University – sequence: 6 givenname: Byeong Hwa surname: Jeon fullname: Jeon, Byeong Hwa organization: Chungnam National University – sequence: 7 givenname: Jin Ho surname: Lee fullname: Lee, Jin Ho email: jhlee@hnu.kr organization: Hannam University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28875561$$D View this record in MEDLINE/PubMed |
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| Snippet | In this study, we fabricated a nerve guide conduit (NGC) with nerve growth factor (NGF) gradient along the longitudinal direction by rolling a porous... Abstract In this study, we fabricated a nerve guide conduit (NGC) with nerve growth factor (NGF) gradient along the longitudinal direction by rolling a porous... |
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| SubjectTerms | Cell culture Cell proliferation Concentration gradient growth factor gradient Growth factors Nerve growth factor nerve guide conduit Nerve guides nerve regeneration Neurotrophic factors Pheochromocytoma cells Polycaprolactone Rats Regeneration Rodents Sciatic nerve |
| Title | Enhanced peripheral nerve regeneration through asymmetrically porous nerve guide conduit with nerve growth factor gradient |
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