H-Phosphonate-Mediated Amination of Quinoline N-Oxides with Tertiary Amines: A Mild and Metal-Free Synthesis of 2-Dialkylaminoquinolines

A synthetic strategy has been developed for the synthesis of 2‐dialkylaminoquinolines from easily available quinoline N‐oxides, tertiary amines, diisopropyl H‐phosphonate and carbon tetrachloride (CCl4) in one pot under metal‐free conditions at room temperature.

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Bibliographic Details
Published inAdvanced synthesis & catalysis Vol. 356; no. 9; pp. 1979 - 1985
Main Authors Chen, Xiaolan, Li, Xu, Qu, Zhibo, Ke, Diandian, Qu, Lingbo, Duan, Likun, Mai, Wenpeng, Yuan, Jinwei, Chen, Jianyu, Zhao, Yufen
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 16.06.2014
WILEY‐VCH Verlag
Wiley
Subjects
2-dialkylaminoquinolines
Amines
Carbon tetrachloride
Catalysis
Chemistry
Chemistry, Applied
Chemistry, Organic
CH activation
CN coupling
H-phosphonates
Physical Sciences
Quinoline
quinoline N-oxides
Science & Technology
Strategy
Synthesis
quinoline N-oxides
REAGENT
2-dialkylaminoquinolines
DIALKYL CHLOROPHOSPHATES
DESIGN
C-H activation
C-N coupling
H-phosphonates
EFFICIENT
DERIVATIVES
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Summary:A synthetic strategy has been developed for the synthesis of 2‐dialkylaminoquinolines from easily available quinoline N‐oxides, tertiary amines, diisopropyl H‐phosphonate and carbon tetrachloride (CCl4) in one pot under metal‐free conditions at room temperature.
Bibliography:National Natural Science Foundation of China - No. 21072178
ark:/67375/WNG-FWQMJ6JS-M
Technology and Science talent Cultivation Project in Zhengzhou City - No. 112PLJRC359
ArticleID:ADSC201301065
istex:E9EAF3B98F298AB1816BC77716C5F30C6E85D342
Innovation Specialist Projects of Henan Province - No. 114200510023
The Special Fund for the Doctoral Program of Higher Education - No. 20124101110003
Foundational and Frontier Technology Research Foundation of Henan Province - No. 132300410027
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201301065