Synthesis and biological study of novel methylene-bis-chalcones and substituted methylene-bis-pyrimidines/pyrimidinones
A series of novel methylene-bis-chalcones was prepared by the reaction of 5,5'-methylene-bis-salicyl-aldehyde with different acetophenones, subsequent treatment of methylene-bis-chalcones with urea/thiourea gave the corresponding methylene-bis-pyrimidinones/ methylene-bis-mereaptopyrimidines in...
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Published in | Journal of heterocyclic chemistry Vol. 44; no. 5; pp. 1181 - 1185 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
HOBOKEN
Wiley
01.09.2007
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Subjects | |
Online Access | Get more information |
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Summary: | A series of novel methylene-bis-chalcones was prepared by the reaction of 5,5'-methylene-bis-salicyl-aldehyde with different acetophenones, subsequent treatment of methylene-bis-chalcones with urea/thiourea gave the corresponding methylene-bis-pyrimidinones/ methylene-bis-mereaptopyrimidines in good yields. Characterization of the new compounds has been done by means of IR, H-1 NMR, MS and elemental analysis. The antibacterial, antitubercular and antifungal activity of the compounds has also been evaluated. |
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ISSN: | 0022-152X 1943-5193 |
DOI: | 10.1002/jhet.5570440534 |