Synthesis and biological study of novel methylene-bis-chalcones and substituted methylene-bis-pyrimidines/pyrimidinones

A series of novel methylene-bis-chalcones was prepared by the reaction of 5,5'-methylene-bis-salicyl-aldehyde with different acetophenones, subsequent treatment of methylene-bis-chalcones with urea/thiourea gave the corresponding methylene-bis-pyrimidinones/ methylene-bis-mereaptopyrimidines in...

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Bibliographic Details
Published inJournal of heterocyclic chemistry Vol. 44; no. 5; pp. 1181 - 1185
Main Authors Nagaraj, Adki, Reddy, Cherkupally Sanjeeva
Format Journal Article
LanguageEnglish
Published HOBOKEN Wiley 01.09.2007
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
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ACID-ESTERS
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Summary:A series of novel methylene-bis-chalcones was prepared by the reaction of 5,5'-methylene-bis-salicyl-aldehyde with different acetophenones, subsequent treatment of methylene-bis-chalcones with urea/thiourea gave the corresponding methylene-bis-pyrimidinones/ methylene-bis-mereaptopyrimidines in good yields. Characterization of the new compounds has been done by means of IR, H-1 NMR, MS and elemental analysis. The antibacterial, antitubercular and antifungal activity of the compounds has also been evaluated.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.5570440534