Nicolau Syndrome: three cases and review

Nicolau Syndrome, also known as livedo‐like dermatitis (LLD) or embolia cutis medicamentosa (ECM), is an infrequent complication following intramuscular and intra‐articular injection of various drugs. This rare entity is characterized by severe pain and erythematous‐ecchymotic reticular lesions at t...

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Bibliographic Details
Published inInternational journal of dermatology Vol. 45; no. 11; pp. 1326 - 1328
Main Authors Luton, Kelli, Garcia, Carlos, Poletti, Eduardo, Koester, Glen
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.11.2006
Blackwell Science
Subjects
Adult
Biological and medical sciences
Dermatology
Diclofenac - administration & dosage
Diclofenac - adverse effects
Female
Humans
Injections, Intramuscular - adverse effects
Male
Medical sciences
Penicillin G - administration & dosage
Penicillin G - adverse effects
Skin - drug effects
Skin - pathology
Skin Diseases, Vascular - chemically induced
Syndrome
Vitamin B 12 - administration & dosage
Vitamin B 12 - adverse effects
Dermatology
Review
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Summary:Nicolau Syndrome, also known as livedo‐like dermatitis (LLD) or embolia cutis medicamentosa (ECM), is an infrequent complication following intramuscular and intra‐articular injection of various drugs. This rare entity is characterized by severe pain and erythematous‐ecchymotic reticular lesions at the injection site, which in many cases lead to necrotic ulcers and scarring. We report three cases of Nicolau Syndrome following injection of diclofenac, penicillin G, and cyanocobalamin.
ISSN:0011-9059
1365-4632
DOI:10.1111/j.1365-4632.2006.02674.x