Changes in renal vessels associated with long-term administration of angiotensin converting enzyme inhibitor in Zucker fatty rats

• Published in: Journal of Smooth Muscle Research Vol. 53; pp. 20 - 30
• Main Authors: Nakanishi, Kazushige, Nagai, Yohko, Akimoto, Tatsuo, Yamanaka, Nobuaki
• Format: Journal Article
• Language: English
• Published: Japan Japan Society of Smooth Muscle Research 01.01.2017; Japan Science and Technology Agency
• Subjects: ACEI; afferent arteriole; Angiotensin-converting enzyme inhibitors; Angiotensin-Converting Enzyme Inhibitors - administration & dosage; Angiotensin-Converting Enzyme Inhibitors - adverse effects; Angiotensin-Converting Enzyme Inhibitors - pharmacology; Animals; Arterioles; Arterioles - cytology; Blood pressure; Blood Pressure - drug effects; Cell Proliferation - drug effects; Diuretics; Enzymes; Kidney - blood supply; Kidneys; Male; Muscle, Smooth, Vascular - cytology; Muscle, Smooth, Vascular - drug effects; Original; Peptidyl-dipeptidase A; Proteinuria; Rats, Zucker; Sensory neurons; Smooth muscle; Time Factors; Zucker fatty rat
• ISSN: 0916-8737; 1884-8796
• DOI: 10.1540/jsmr.53.20

Background Recently, we showed that long-term angiotensin receptor blocker (ARB) administration induced unusual proliferative changes in smooth muscle cells (SMCs) of afferent arterioles of the kidneys of Zucker fatty rats (ZFRs). In this study, we investigated renal afferent arteriolar changes induced by the long-term administration of an angiotensin converting enzyme inhibitor (ACEI) in ZFRs. Materials and Methods Fourteen 6-week-old male ZFRs were divided into two groups (n=14): the ZFR+ACEI group (n=6) was fed a standard diet containing ACEI (Enalapril, 2 mg/kg/day), and the ZFR control group (n=8) for 12 weeks. Blood pressure and proteinuria were examined and morphological studies on kidneys were performed. Results Remarkable proliferative changes in the afferent arteriolar SMCs were frequently observed in the group given ACEI; (66.1 ± 12.9%) compared with the control group (1.77 ± 1.56%, P<0.001). Conclusions It was indicated that long-term ACEI administration induced unusual proliferative changes in SMCs in afferent arterioles of ZFRs. These changes could reduce intraglomerular pressure by narrowing the lumens of afferent arterioles, but they could cause irreversible damage to the arterioles.