Age-Associated Abnormalities of Water Homeostasis

Deficits in renal function, thirst, and responses to osmotic and volume stimulation have been repeatedly demonstrated in older populations. The lessons learned over the past six decades serve to emphasize the fragile nature of water balance characteristic of aging. Older individuals are at increased...

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Bibliographic Details
Published inEndocrinology and metabolism clinics of North America Vol. 52; no. 2; p. 277
Main Authors Cowen, Laura E, Hodak, Steven P, Verbalis, Joseph G
Format Journal Article
LanguageEnglish
Published United States 01.06.2023
Subjects
Aged
Aging - physiology
Homeostasis - physiology
Humans
Hyponatremia
Thirst - physiology
Water
Water-Electrolyte Balance - physiology
Hyponatremia
Hypernatremia
Diabetes insipidus
Aging
Arginine vasopressin
Thirst
Osmolality
SIAD
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Summary:Deficits in renal function, thirst, and responses to osmotic and volume stimulation have been repeatedly demonstrated in older populations. The lessons learned over the past six decades serve to emphasize the fragile nature of water balance characteristic of aging. Older individuals are at increased risk for disturbances of water homeostasis due to both intrinsic disease and iatrogenic causes. These disturbances have real-life clinical implications in terms of neurocognitive effects, falls, hospital readmission and need for long-term care, incidence of bone fracture, osteoporosis, and mortality.
ISSN:1558-4410
DOI:10.1016/j.ecl.2022.11.002